科研之友
微信
新浪微博
Facebook
分享链接
摘要
The anti-inflammation effect of N-desulfated heparin, a non-anticoagulant heparin, was assessed in vivo and in vitro. The data showed that N-desulfated heparin significantly inhibited the leukocytes recruitment to the peritoneal cavity in a dose-dependent manner. It also suppressed the picrylchloride induced delayed-type hypersensitivity reaction at both induction phase and effector phase. However, N-desulfated heparin did not affect the acute hepatitis induced by carbon tetrachloride and ear edema induced by xylene. The in vitro study of the adhesion of human Jurkat T cells to endothelial cell line ECV-304 showed that N-desulfated heparin could decrease binding rate stimulated by IL-2, IFN-gamma or TNF-alpha. Our results indicated that N-desulfated heparin has anti-inflammation property and the inhibition of the migration of immunity cells maybe one of its mechanisms.
