A new strategy for targeted delivery of non-water-soluble porphyrins in chitosan-albumin capsules

作者：Lebedeva Natalya Sh; Gubarev Yury A^*; Yurina Elena S; Smirnova Ekaterina N; Syrbu Sergey A

来源：Colloid and Polymer Science, 2017, 295(11): 2173-2182.

DOI：10.1007/s00396-017-4191-9

• Protein
• Chitosan
• Porphyrin
• Encapsulation
• Targeted therapy

This study was focused on obtaining polymer complex of 5-(4'-N-tert-butyloxycarbonylglicinaminophenyl)-10,15,20-triphenylporphine and 5-(4'-amonophenyl)-10,15,20-triphenylporphine with chitosan. The polymer complexes were characterized spectrally and calorimetrically. The existence of a substituent capable of forming hydrogenic complexes with proteins and other biopolymers in porphyrins provides an effective immobilization of a photosensitizer. Binding with porphyrins was found to result in twisting the chitosan globule and encapsulation of porphyrins. Coating of polymer complex with bovine serum albumin promotes neutralization of zeta potential and formation of 180-nm capsules. As the result of the study, a new universal strategy of water insoluble preparation encapsulation in biopolymers for targeted delivery of drugs and their further release was suggested.

• 出版日期2017-11