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摘要
Background: Down syndrome (DS) is a neurodegenerative disease with unknown mechanisms. beta-Amyloid peptide (A beta) and tau protein (Tau) are known to play a role, while vitamin A (VA) has an effect on normal neurological function. In a case-control study, we quantitatively evaluated whole brain and hippocampal volumes of DS children and analyzed the correlation of hippocampal volumes with blood levels of A beta, Tau and VA. @@@ Methods: All subjects underwent magnetic resonance imaging (MRI) of the brain. The whole brain and hippocampal volumes were quantitatively analyzed using voxel-based morphometry (VBM) and stereology respectively. The blood levels of A beta, Tau, and VA were detected by enzyme-linked immunosorbent assay and high-performance liquid chromatography, respectively. @@@ Results: Thirty DS children and twenty healthy controls were recruited. Whole brain and hippocampal volumes were significantly smaller in individuals with DS than in healthy controls. In both groups, whole brain and hippocampal volumes increased in accordance with age. The results of correlation analysis suggested that A beta 42/A beta 40 and VA are associated with hippocampal volume in DS patients. @@@ Conclusion: DS children exhibited neurodevelopmental defects, even at an early age. A beta 42/A beta 40 and VA may affect hippocampal volume in DS patients.
- 出版日期2019-3
- 单位重庆医科大学
