Novel Oncogene-Induced Metastatic Prostate Cancer Cell Lines Define Human Prostate Cancer Progression Signatures

作者：Ju Xiaoming; Ertel Adam; Casimiro Mathew C; Yu Zuoren; Meng Hui; McCue Peter A; Walters Rhonda; Fortina Paolo; Lisanti Michael P; Pestell Richard G^*

来源：Cancer Research, 2013, 73(2): 978-989.

DOI：10.1158/0008-5472.CAN-12-2133

Herein, murine prostate cancer cell lines, generated via selective transduction with a single oncogene (c-Myc, Ha-Ras, and v-Src), showed oncogene-specific prostate cancer molecular signatures that were recapitulated in human prostate cancer and developed lung metastasis in immune-competent mice. Interrogation of two independent retrospective cohorts of patient samples using the oncogene signature showed an ability to distinguish tumor from normal prostate with a predictive value for prostate cancer of 98% to 99%. In a blinded study, the signature algorithm showed independent substratification of reduced recurrence-free survival by Kaplan-Meier analysis. The generation of new oncogene-specific prostate cancer cell lines that recapitulate human prostate cancer gene expression, which metastasize in immune-competent mice, are a valuable new resource for testing targeted therapy, whereas the molecular signatures identified herein provides further value over current gene signature markers of prediction and outcome. Cancer Res; 73(2); 978-89.

• 出版日期2013-1-15