Alokicenones A-H, eight tetrahydroanthracenes from the mangrove-derived Streptomyces sp HN-A101

作者：Zhang, Dashan; Jiang, Yongjun; Li, Jiaqi; Zhang, Haojian; Ding, Wanjing; Ma, Zhongjun^*

来源：Tetrahedron, 2018, 74(46): 6667-6672.

DOI：10.1016/j.tet.2018.09.049

• Alokicenones A-H
• Mangrove-derived Streptomyces
• Cytotoxicity
• ROCK2 inhibitory activities
• BRD4 inhibitory activities

Alokicenones A-H (1-8), eight new tetrahydroanthracenes and one known okicenone (9) were identified from the secondary metabolites of mangrove-derived Streptomyces sp. HN-A101. Their structures were elucidated by HRESIMS and NMR spectroscopic data. The absolute configurations of them were determined by the calculated and experimental ECD curves. Compounds 1-2 and 9 showed moderate cytotoxicity against HCT116 and SW620 cancer cell lines with IC50 values from 0.63 to 7.73 mu M. In addition, compounds 1-3 and 7-9 also exhibited inhibitory activities against ROCK2 or BRD4.

• 出版日期2018-11-15
• 单位浙江大学