Degradable performance and bio-mineralization function of bioglass/PLA-PEG-PLA/poly(Lactic acid) tissue engineering scaffold in SBF

作者：Ge, Jianhua^*; Wang, Yingjun; Chen, Xiaofeng; Zheng, Yudong

来源：Acta Materiae Compositae Sinica, 2013, 30(6): 96-100.

• Bio mineralizations
• Degradation rate
• Hydroxyl apatites
• Mass loss ratio
• PLA-PEG-PLA
• Poly lactic acid
• Simulated body fluids
• Tissue engineering scaffold

The degradable performance and bio-mineralization function of bioglass/poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) block copolymer (PLA-PEG-PLA)/poly(lactic acid) tissue engineering scaffolds were systematically studied in the simulated body fluid (SBF) by measuring pH value of SBF, the mass loss ratio of the scaffolds and analyzing SEM pictures, XRD and FTIR spectra of scaffolds'surface. The results show that in SBF, the pH value of SBF with tissue engineering scaffolds and the mass of scaffolds decrease with the prolongation of time. At the same time, the present of bioglass makes pH value of SBF increase and the present of PLA-PEG-PLA makes pH value of SBF decrease. SEM pictures, XRD and FTIR spectra show that there appears the deposition of carbonate hydroxyl apatite on the surface of the bioglass/PLA-PEG-PLA/poly(lactic acid) tissue engineering scaffolds, and the degradation rate of PLA-PEG-PLA is quicker than that of PLA in SBF, because the present of PLA-PEG-PLA in the sample immersed in SBF for 7 d could not be detected by FTIR.

• 出版日期2013-12
• 单位北京科技大学; 华南理工大学