Add-On Memantine Treatment for Bipolar II Disorder Comorbid with Alcohol Dependence: A 12-Week Follow-Up Study

作者：Lee Sheng Yu; Wang Tzu Yun; Chen Shiou Lan; Chang Yun Hsuan; Chen Po See; Huang San Yuan; Tzeng Nian Sheng; Wang Liang Jen; Lee I Hui; Chen Kao Ching; Yang Yen Kuang; Hong Jau Shyong; Lu Ru Band^*

来源：Alcoholism: Clinical and Experimental Research , 2018, 42(6): 1044-1050.

DOI：10.1111/acer.13640

• Memantine
• Bipolar II Disorder
• Alcohol Dependence
• Cytokines
• BDNF

BackgroundBipolar disorder (BD), especially BD-II, is frequently comorbid with alcohol dependence. Because BD-II and alcohol dependence are neurodegenerative disorders, agents with anti-inflammatory and neurotrophic effects might provide effective therapy. We investigated whether add-on memantine to regular valproic acid treatment ameliorated clinical symptoms, reduced alcohol use, and cytokine levels, and increased plasma brain-derived neurotrophic factor (BDNF) in BD-II patients with comorbid alcohol dependence.
MethodsIn a single-arm 12-week clinical trial, BD-II patients with comorbid alcohol dependence (n=45) undergoing regular valproic acid treatments were given add-on memantine (5mg/d). Symptom severity, alcohol use, cytokine (plasma tumor necrosis factor- and C-reactive protein [CRP], transforming growth factor-1 [TGF-1], interleukin-8 [IL-8], IL-10), and plasma BDNF levels were regularly assessed.
ResultsMean within-group decreases in Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) scores, alcohol use, CRP, BDNF, and IL-8 levels were significantly different from baseline after 12weeks of treatment. We found no significant correlation between alcohol use levels and changes in HDRS or YMRS scores. The correlation between reduced alcohol use and reduced TGF-1 level was significant (B=0.003, p=0.019).
ConclusionsBD-II comorbid with alcohol dependence might benefit from add-on memantine treatment, which significantly reduced clinical severity, alcohol use, and plasma cytokine levels, and increased BDNF levels.

• 出版日期2018-6
• 单位河北医科大学