The effect of synthesis medium on structure and drug delivery behavior of CTAB-assisted sol-gel derived nanoporous calcium-magnesium-silicate

作者：Ghadiri Sadegh; Hassanzadeh Tabrizi S A^*; Bigham Ashkan

来源：Journal of Sol-Gel Science and Technology, 2017, 83(1): 229-236.

DOI：10.1007/s10971-017-4404-1

• Sol-gel
• Drug delivery
• Mesoporous
• Calcium-magnesium-silicate
• Ibuprofen

In the present study, mesoporous calcium-magnesium-silicate was prepared via cetyltrimethylammonium bromide (CTAB)-assisted sol-gel method in both acidic and alkaline mediums. The effects of synthesis medium on structural properties, and drug delivery behavior of mesoporous calcium-magnesium-silicate by using ibuprofen as model drug are investigated. The X-ray diffraction results of the samples calcined at 600 A degrees C showed that the sample synthesized at alkaline environment is composed of CaSiO3 and CaMgSiO4 phases, whereas in acidic condition the sample consists of akermanite, CaMgSiO4, CaSiO3, and MgO. The specific surface area of the mesoporous calcium-magnesium-silicate samples prepared in acidic and alkaline conditions were 220 and 140 m(2)/g, respectively. The mesoporous calcium-magnesium-silicate sample synthesized in the acidic condition resulted in smaller particles with a size ranging between 50 and 100 nm. Encapsulation of ibuprofen into mesoporous calcium-magnesium-silicate was studied as a function of time.
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• 出版日期2017-7