A New Era of Podocyte-Targeted Therapy for Proteinuric Kidney Disease

作者:Haraldsson Borje*
来源:New England Journal of Medicine, 2013, 369(25): 2453-2454.
DOI:10.1056/NEJMe1312835

摘要

Stage 5 chronic kidney disease, which heralds end-stage renal disease (ESRD) and the need for dialysis or transplantation, is a major and rapidly increasing socioeconomic burden worldwide. In 2011, approximately 113,000 patients began dialysis therapy in the United States.(1) At the end of 2011, approximately 430,000 Americans were on dialysis and another 186,000 had functioning kidney transplants, which brought the total number of patients with ESRD in the United States to 616,000.(1) Glomerular disease is the most common cause of ESRD, accounting for almost two thirds of cases. In recent years, a complex and fascinating world of molecular mechanisms that ...