Association between dietary inflammatory index and inflammatory markers in the HELENA study

作者：Shivappa Nitin^*; Hebert James R; Marcos Ascension; Diaz Ligia Esperanza; Gomez Sonia; Nova Esther; Michels Nathalie; Arouca Aline; Gonzalez Gil Esther; Frederic Gottrand; Gonzalez Gross Marcela; Castillo Manuel J; Manios Yannis; Kersting Mathilde; Gunter Marc J; De Henauw Stefaan; Antonios Kafatos; Widhalm Kurt; Molnar Denes; Moreno Luis; Huybrechts Inge

来源：Molecular Nutrition & Food Research, 2017, 61(6): 1600707.

DOI：10.1002/mnfr.201600707

• Adolescents
• Cross-sectional
• Diet
• Inflammation
• HELENA

Background: Previous research has shown that diet is associated with low-grade systemic inflammation among adults. However, no study has yet been conducted to explore the association between inflammatory potential of diet and low-grade systemic inflammation among adolescents whose dietary behavior may be different from adults.
Methods and Results: We examine the predictive ability of 24-h recall-derived dietary inflammatory index (DII) scores on inflammation among 532 European adolescents in the HELENA cross-sectional study. The DII is a literature-derived dietary index developed to predict inflammation. The DII was calculated per 1000 calories and was tested against C-reactive protein, ILs-1,2,4,10, TNF-alpha, ICAM, vascular cell adhesion molecule (VCAM), and IFN-gamma. All inflammatory markers had nonnormal distributions and therefore were log transformed. Analyses were performed using multivariable linear regression, adjusting for age, sex, city, BMI, smoking, and physical activity. Pro-inflammatory diet (higher DII scores) was associated with increased levels of various inflammatory markers: TNF-alpha, IL-1, 2, IFN-gamma, and vascular cell adhesion molecule (b(DIIt3vs1) = 0.13, 95% CI: 0.001, 0.25; 0.13, 95% CI 0.001, 0.25; 0.40, 95% CI: 0.03, 0.77; 0.53, 95% CI: 0.05, 1.01; 0.07, 95% CI: 0.01, 0.13, respectively).
Conclusion: These results reinforce the fact that diet, as a whole, plays an important role in modifying inflammation in adolescents.

• 出版日期2017-6