A mathematical model of a P53 oscillation network triggered by DNA damage

作者：Xia Jun-Feng; Jia Ya^*

来源：Chinese Physics B, 2010, 19(4): 040506.

DOI：10.1088/1674-1056/19/4/040506

• P53 oscillation network
• DNA damage signal
• time delay
• kinetic model

Taking the interaction between a DNA damage repair module, an ATM module, and a P53-MDM2 oscillation module into account, this paper presents a mathematical model of a P53 oscillation network triggered by a DNA damage signal in individual cells. The effects of the DNA damage signal and the delay time of P53-induced MDM2 expression on the behaviours of the P53 oscillation network are studied. In the oscillatory state of the P53-MDM2 oscillator, it is found that the pulse number of P53-P oscillation increases with the increase of the initial DNA damage signal, whereas the amplitude and the period of P53-P oscillation are fixed for different initial DNA damage signals, and the period numbers of P53-P oscillations decrease with the increase of time delay of MDM2 expression induced by P53. These theoretical predictions are consistent with previous experimental results. The combined negative feedback of P53-MDM2 with the time delay of P53-induced MDM2 expression causes oscillation behaviour in the P53 network.

• 出版日期2010-4
• 单位华中师范大学