Nano-zinc Coordination with the Ligands of Carboplatin, Oxaliplatin and Nedaplatin. Synthesis, Characterization and Biological Properties

作者：Dehkharghani Rahebeh Amiri^*; Keshtpoor Farzaneh; Niaki Hadis Yazdani

来源：Letters in Organic Chemistry, 2015, 12(7): 491-496.

DOI：10.2174/1570178612666150507223126

• Biologically active
• carboplatin
• nano-scalled ZnO
• nedaplatin
• oxaliplatin
• synthesis
• zinc-complexes

The replacement of platinum in carboplatin, oxaliplatin and nedaplatin by zinc metal ( in bulk and nano-scalled) produces biologically active compounds with increased solubility in water. We compared, in this work, three synthesized zinc-complexes from the ligands of platinum-anticancer drugs. The structural characterization of the products has been determined on the basis of their atomic absorption spectroscopy, elemental analysis, FT-IR, H-1 and C-13 NMR spectra. The crystalline structure and morphology of the products have been shown by XRD and SEM techniques. The antibacterial activities of the complexes have been examined through the growth inhibitory zone and minimal inhibitory concentrations.

• 出版日期2015