Negative Urgency and Ventromedial Prefrontal Cortex Responses to Alcohol Cues: fMRI Evidence of Emotion-Based Impulsivity

作者：Cyders Melissa A^*; Dzemidzic Mario; Eiler William J; Coskunpinar Ayca; Karyadi Kenny; Kareken David A

来源：Alcoholism: Clinical and Experimental Research , 2014, 38(2): 409-417.

DOI：10.1111/acer.12266

• fMRI Imaging
• Alcohol
• Olfaction
• Emotion
• Impulsivity

BackgroundRecent research has highlighted the role of emotion-based impulsivity (negative and positive urgency personality traits) for alcohol use and abuse, but has yet to examine how these personality traits interact with the brain%26apos;s motivational systems. Using functional magnetic resonance imaging (fMRI), we tested whether urgency traits and mood induction affected medial prefrontal responses to alcohol odors (AcO). %26lt;br%26gt;MethodsTwenty-seven social drinkers (mean age=25.2, 14 males) had 6 fMRI scans while viewing negative, neutral, or positive mood images (3 mood conditions) during intermittent exposure to AcO and appetitive control (AppCo) aromas. %26lt;br%26gt;ResultsVoxel-wise analyses (p%26lt;0.001) confirmed [AcO%26gt;AppCo] activation throughout medial prefrontal cortex (mPFC) and ventromedial PFC (vmPFC) regions. Extracted from a priori mPFC and vmPFC regions and analyzed in Odor (AcO, AppCo)xMood factorial models, AcO activation was greater than AppCo in left vmPFC (p%26lt;0.001), left mPFC (p=0.002), and right vmPFC (p=0.01) regions. Mood did not interact significantly with activation, but the covariate of trait negative urgency accounted for significant variance in left vmPFC (p=0.01) and right vmPFC (p=0.01) [AcO%26gt;AppCo] activation. Negative urgency also mediated the relationship between vmPFC activation and both (i) subjective craving and (ii) problematic drinking. %26lt;br%26gt;ConclusionsThe trait of negative urgency is associated with neural responses to alcohol cues in the vmPFC, a region involved in reward value and emotion-guided decision-making. This suggests that negative urgency might alter subjective craving and brain regions involved in coding reward value.

• 出版日期2014-2