Maternal vitamin D levels are inversely related to allergic sensitization and atopic diseases in early childhood

作者：Chiu, Chih-Yung; Huang, Shih-Yin; Peng, Yu-Chieh; Tsai, Ming-Han; Hua, Man-Chin; Yao, Tsung-Chieh; Yeh, Kuo-Wei^*; Huang, Jing-Long

来源：Pediatric Allergy and Immunology, 2015, 26(4): 337-343.

DOI：10.1111/pai.12384

• 25-hydroxyvitamin D
• allergen sensitization
• asthma
• eczema
• vitamin D

BackgroundThere are few studies addressing the impact of maternal vitamin D status on the vitamin D levels in offspring, their sensitization to common allergens and atopic disease development. @@@ MethodsChildren aged 0 through 4yr from a birth cohort in the Prediction of Allergies in Taiwanese Children (PATCH) study were enrolled. Time series of serum 25-hydroxyvitamin D (25(OH)D) levels were measured in maternal blood before delivery, cord blood, and at age 1.5, 3, and 4 using an electrochemiluminescence-based assay. Specific IgE antibodies against food and inhalant allergens were measured at 6months, and 1, 1.5, 2, 3, and 4yr of age. @@@ ResultsA total of 164 mother-child pairs from a birth cohort were recruited in this study. The mean levels of maternal 25(OH)D were 23.27.7ng/ml with a high (up to 80%) prevalence of insufficient vitamin D status (< 30ng/ml). A significant correlation was seen between maternal and cord blood 25(OH)D levels (p<0.001), and a persistent lower 25(OH)D level was found in children born to mothers with deficient 25(OH)D levels. Deficient maternal 25(OH)D levels (<20ng/ml) appeared to be associated with a higher prevalence of allergen sensitization before age 2. Higher maternal 25(OH)D levels were significantly associated with lower risk of eczema (OR 0.12; 95% CI 0.02-0.63; p=0.012) and asthma (OR 0.22; 95% CI 0.06-0.92; p=0.038) at age 4. @@@ ConclusionsLow maternal 25(OH)D levels appear not only to be associated with an increase in the prevalence of allergic sensitization but also the risk of eczema and asthma in early childhood.

• 出版日期2015-6
• 单位长春大学