Application of flow chemistry to the reduction of nitriles to aldehydes

作者：Munoz Juan de M; Alcazar Jesus^*; de la Hoz Antonio; Diaz Ortiz Angel

来源：Tetrahedron Letters, 2011, 52(46): 6058-6060.

DOI：10.1016/j.tetlet.2011.08.144

• Flow chemistry
• Selective reduction
• DIBAL-H
• Microreactor

Reduction of nitriles to aldehydes with diisobutylaluminium hydride (DIBAL-H) is an important transformation in organic chemistry. But the use of this reaction is limited for the lack of reproducibility due to the instability of the intermediates formed. In the current article we disclose the improvement of the reaction applying continuous flow technology.

• 出版日期2011-11-16