Asymmetric hydrogenation of aromatic ketones catalyzed by (1S,2S)-DPEN-modified Ru-PPh(3)/gamma-Al(2)O(3) catalyst

作者：Tang Bo; Xiong Wei^*; Liu Ele Rong; Jia Yun; Wang Jin Bo; Chen Hua; Li Xian Jun

来源：Tetrahedron: Asymmetry , 2008, 19(11): 1397-1401.

DOI：10.1016/j.tetasy.2008.05.014

The asymmetric hydrogenations of acetophenone and its derivatives over the (1S,2S)-DPEN-modified Ru-PPh(3)/gamma-Al(2)O(3) were investigated. The effects of reaction conditions on the asymmetric hydrogenation of acetophenone are discussed in detail. The results showed that this catalyst had high activity and moderate enantioselectivity for the asymmetric hydrogenation of acetophenone and its derivatives. Under the optimum conditions, the conversion of acetophenone was up to 100%, and the enantioselectivity for the formation of (R)-phenyl ethanol was 77.7% ee. The chiral alcohol products could be easily separated by centrifugation, while the catalyst could be reused several times.

• 出版日期2008-6-16
• 单位重庆科技学院; 四川大学