Absolute stereochemistry of pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1

作者：Yamazaki Hiroyuki; Ugaki Narihiro; Matsuda Daisuke; Tomoda Hiroshi^*

来源：Journal of Antibiotics, 2010, 63(6): 315-318.

DOI：10.1038/ja.2010.39

• absolute stereochemistry
• acyl-CoA:cholesterol acyltransferase
• fungal metabolite
• lipid droplet formation
• Penicillium cecidicola
• pentacecilides D

The structure of a new pentacecilide congener, pentacecilide D, produced by Penicillium cecidicola FKI-3765-1 was elucidated by various NMR experiments. The absolute stereochemistry of pentacecilides was elucidated by using the modified Mosher method for pentacecilide C. The inhibitory activity of all pentacecilides against lipid droplet formation and acyl-CoA:cholesterol acyltransferase isozymes was compared. The Journal of Antibiotics (2010) 63, 315-318; doi:10.1038/ja.2010.39; published online 23 April 2010

• 出版日期2010-6