Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection

作者：Fecury Amanda Alves; Costa de Almeida Marcella Kelly; dos Santos Kemper Nunes; Freitas Andrei da Silva; Loureiro Dantas Socorro de Fatima; da Costa Carlos Araujo; Crescente Angelo Barlleta; Medeiros de Sousa Rita Catarina; de Brito Elza Baia; Nassiri Reza; Lampe Elizabeth; Martins Luisa Caricio^*

来源：Revista da Sociedade Brasileira de Medicina Tropical, 2014, 47(1): 90-92.

DOI：10.1590/0037-8682-0008-2012

• Hepatitis C virus
• Genotype
• Histopathology

Introduction: The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression. Methods: Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation. Results: Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis. Conclusions: HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction.

• 出版日期2014-2