Assessment of Biochemical Recurrence Rate in Patients With Pathologically Confirmed Insignificant Prostate Cancer

作者：Capitanio Umberto; Ahyai Sasha; Graefen Markus; Jeldres Claudio; Shariat Shahrokh F; Erbersdobler Andreas; Schlomm Thorsten; Haese Alexander; Steuber Thomas; Heinzer Hans; Perrotte Paul; Peloquin Frangois; Pharand Daniel; Arjane Philippe; Huland Hartwig; Karakiewicz Pierre I^*

来源：Urology, 2008, 72(6): 1208-1211.

DOI：10.1016/j.urology.2008.04.053

OBJECTIVES To examine the rate of biochemical recurrence (BCR) in patients with pathologically confirmed insignificant prostate cancer (PIPCa).
METHODS A total of 1358 patients underwent open retropubic radical prostatectomy at the University Medical Center Eppendorf in Hamburg, Germany, and their specimens were whole-mounted, step-sectioned, and subjected to computer-based three-dimensional reconstruction. We identified patients who fulfilled the Epstein criteria for definition of PIPCa (tumor volume <= 0.5 mL, Gleason score <= 6, organ-confined disease) and we compared the BCR-free rates between the PIPCa and non-PIPCa groups.
RESULTS Pathologically confirmed insignificant prostate cancer was found in 69 patients (5%). At 1, 2, 5, and 10 years, the BCR-free rate for PIPCa patients was 100% vs, respectively, 97%, 91%, 74%, and 38% for other patients (log-rank P <.0001).
CONCLUSIONS In patients with PIPCa, radical prostatectomy results in perfect biochemical recurrence rates, which confirms the validity of the PIPCa definition. UROLOGY 72: 1208-1211, 2008.

• 出版日期2008-12