A facile and highly chemoselective synthesis of 1,2-disubstituted benzimidazoles using hierarchical nanoporous material

作者：Senthilkumar Samuthirarajan; Kumarraja Mayilvasagam^*

来源：Tetrahedron Letters, 2014, 55(12): 1971-1974.

DOI：10.1016/j.tetlet.2014.01.140

• Nanoporous zeolite
• Chemoselectivity
• 1,2-Disubstituted benzimidazole
• Solid acid
• o-Phenylenediamine
• Aromatic aldehyde

A highly ordered nanoporous aluminosilicate (MMZ(Y)) is prepared and employed as a catalyst for the synthesis of benzimidazoles from 1,2-diaminobenzene and aromatic aldehydes. In all the cases, the reactions are highly chemoselective and afford 1,2-disubstituted benzimidazoles in excellent yield. The catalyst was characterized by electron microscopy and X-ray methods and its other advantages like functional tolerance, mildness of the reaction conditions, easy separation, and reusability are also highlighted.

• 出版日期2014-3-19