Two Novel Potential Anticonvulsant Salts of 5-Amino-2-Sulfonamide-1,3,4-Thiadiazole

作者：Diaz Jorge R A; Cami Gerardo E; Gonzalez Malva L; Pedregosa Jose C; Vega Daniel R^*

来源：Journal of Chemical Crystallography, 2011, 41(8): 1114-1119.

DOI：10.1007/s10870-011-0054-2

• Sulfonamides
• Sulfonamide salts
• Crystal structure

Two crystal structures of sulfonamide salts were studied by X-Ray diffraction. The compound C2H5N4O2S2 (+)center dot H2O center dot Cl- (I), (Hats center dot H2O center dot Cl, Hats = protonated 5-amino-2-sulfonamide-1,3,4-thiadiazole) crystallizes in orthorhombic space group, P2(1)2(1)2(1), with unit cell parameters a = 10.047(4), b = 5.186(2), c = 16.766(6) and the compound C2H5N4O2S2 (+)center dot CH3O3S- (II), crystallizes in monoclinic space group, Cc, with unit cell parameters a = 5.378(3), b = 19.707(6), c = 10.014(5) , beta = 99.97(1)A degrees. The molecules in compound I are arranged in a helix of alternating water and Hats molecules. Helixes are interconnected by hydrogen bonds provided by Cl- ions and one ring with a graph set R (6) (4) (12) is determined. The crystal structure of compound II presents mesylate and Hats molecules bonded by two hydrogen bond determining a ring with a graph set R (2) (2) (8).

• 出版日期2011-8