Unique pharmacological property of ISRIB in inhibition of A beta-induced neuronal cell death

作者：Hosoi Toru; Kakimoto Mai; Tanaka Keigo; Nomura Jun; Ozawa Koichiro

来源：Journal of Pharmacological Sciences, 2016, 131(4): 292-295.

DOI：10.1016/j.jphs.2016.08.003

• Amyloid beta
• Alzheimer's disease
• ISRIB

A pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been established. In the present study, we investigated the pharmacological characteristics of the recently identified memory-enhancing compound, ISRIB for the amelioration of AD. ISRIB potently attenuated amyloid beta-induced neuronal cell death at concentrations of 12.5-25 nM, but did not inhibit amyloid beta production in the HEK293T cell line expressing the amyloid precursor protein (APP). These results suggest that ISRIB possesses the unique pharmacological property of attenuating amyloid beta-induced neuronal cell death without affecting amyloid b production.

• 出版日期2016-8
• 单位RIKEN