Application of bis-2-(trimethylsilyl)ethyl diselenide to the synthesis of selenium-containing amino acid derivatives

作者：Yonezawa Tsubasa; Yamaguchi Masahito; Ninomiya Masayuki; Koketsu Mamoru^*

来源：Tetrahedron, 2017, 73(42): 6085-6091.

DOI：10.1016/j.tet.2017.09.004

• Selenation
• Bis-2-(trimethylsilyl)ethyl diselenide
• Selenium-containing amino acid
• Selenocysteine
• Selenoglutathione

Selenium-containing amino acids play a pivotal role as biomaterials for the synthesis of Se-dependent enzymes and repair proteins. Especially, selenocysteine and selenoglutathione are prominently involved in fundamental biological processes. In this study, a series of selenocysteine (Sec) and selenoglutathione (GSeH) derivatives were synthesized via 2-(trimethylsilyl)ethylselenation as a key step. Our findings suggested the relevance and application of a 2-(trimethylsilyl)ethylselenyl group to the Se-containing amino acid synthesis.

• 出版日期2017-10-19