科研之友
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摘要
A new method was developed for simultaneous spatial localization and spectral separation of multiple compounds based on a single echo, by designing the acquisition to place individual compounds in separate frequency encoding bands. This method was specially designed for rapid and robust metabolic imaging of hyperpolarized C-13 substrates and their metabolic products, and was investigated in phantom studies and studies in normal mice and transgenic models of prostate cancer to provide rapid metabolic imaging of hyperpolarized [1-C-13]pyruvate and its metabolic products [1-C-13]lactate and [1-C-13]alanine at spatial resolutions up to 3 mm in-plane. Elevated pyruvate and lactate signals in the vicinity of prostatic tissues were observed in transgenic tumor mice. The multi-band frequency encoding technique enabled rapid metabolic imaging of hyperpolarized C-13 compounds with important advantages over prior approaches, including less complicated acquisition and reconstruction methods.
- 出版日期2011-8
