Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections

作者：Ying, Tianlei^*; Li, Haoyang; Lu, Lu; Dimitrov, Dimiter S.; Jiang, Shibo

来源：Microbes and Infection, 2015, 17(2): 142-148.

DOI：10.1016/j.micinf.2014.11.008

• Coronavirus
• MERS-CoV
• mAbs
• Receptor binding domain (RBD)

The recent Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak poses a serious threat to public health. Here, we summarize recent advances in identifying human neutralizing monoclonal antibodies (mAbs) against MERS-CoV, describe their mechanisms of action, and analyze their potential for treatment of MERS-CoV infections.

• 出版日期2015-2
• 单位复旦大学