A Facile Route for the Synthesis of Novel Heterocyclic Prostaglandin F-2 alpha Analogs

作者:Shankar M; Mohan H Rama*; Prasad U Viplava; Harikrishna M; Rao M P Pareswar; Ravindra A
来源:Journal of Heterocyclic Chemistry, 2014, 51(4): 1086-1093.
DOI:10.1002/jhet.1622

摘要

A general synthetic approach has been developed for heterocyclic prostaglandins (PGF(2) type) starting from the key intermediate (6). (+/-) 6 was obtained from (+/-) -Corey lactone. The key intermediate (+/-) 6 was, in turn, converted in to several new heterocyclic prostaglandins consisting of furan and thiophene moieties in -side chain in two to three steps. Horner-Wadsworth-Emmons reaction and Grignard reaction as the key reactions in these transformations.

  • 出版日期2014-7