摘要
A general synthetic approach has been developed for heterocyclic prostaglandins (PGF(2) type) starting from the key intermediate (6). (+/-) 6 was obtained from (+/-) -Corey lactone. The key intermediate (+/-) 6 was, in turn, converted in to several new heterocyclic prostaglandins consisting of furan and thiophene moieties in -side chain in two to three steps. Horner-Wadsworth-Emmons reaction and Grignard reaction as the key reactions in these transformations.
- 出版日期2014-7