A single-light triggered and dual-imaging guided multifunctional platform for combined photothermal and photodynamic therapy based on TD-controlled and ICG-loaded CuS@mSiO(2)

作者：You, Qing; Sun, Qi; Wang, Jinping; Tan, Xiaoxiao; Pang, Xiaojuan; Liu, Li; Yu, Meng; Tan, Fengping; Li, Nan^*

来源：Nanoscale, 2017, 9(11): 3784-3796.

DOI：10.1039/c6nr09042g

• COPPER SULFIDE NANOPARTICLES
• HOLLOW GOLD NANOSPHERES
• DRUG-DELIVERY
• SILICA NANOPARTICLES
• CONTROLLED-RELEASE
• NANOMATERIALS
• OXYGEN
• PHOTOSENSITIZERS
• NANOPLATFORM
• GRAPHENE

Near-infrared (NIR)-responsive drug delivery systems have received enormous attention because of their good biocompatibility and high biological penetration. In this work, we report a novel 1-tetradecanol (TD)-controlled and indocyanine green (ICG)-loaded CuS@mSiO(2) phototherapy nanoplatform (CuS@mSiO(2)-TD/ICG). The CuS@mSiO(2) nanoparticles prepared by a facile one-pot approach can serve as drug-delivery vehicles to transport the NIR absorbing phototherapeutic agent (ICG) within the mesoporous cavities. Meanwhile a phase-change molecule (PCM), TD, is introduced as a thermosensitive gatekeeper to avoid the premature release of loaded ICG. Noticeably, the combined therapy is irradiated at an 808 nm single-light wavelength, thus performing the photothermal therapy (PTT) based on CuS@mSiO(2) as well as simultaneously triggering the photodynamic (PDT)/PTT effect based on ICG. Furthermore, ICG also has the function of dual in vivo fluorescence imaging and photoacoustic (PA) imaging. This dual imaging-guided and gatekeeper-controlled nanoplatform for the single-light triggered PTT/PDT treatment holds significant promise for future cancer therapy due to their markedly improved therapeutic efficacy and decreased systemic toxicity.

• 出版日期2017-3-21
• 单位天津大学