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摘要
Objective: To evaluate the efficacy and toxicity of cisplatin and vinorelbine (NP) for postoperative adjuvant chemotherapy of completely resected breast cancers. Methods: Between September 1994 and April 2005, 91 Chinese breast cancer patients, with pathologically-confirmed adenocarcinoma in Jiangsu Cancer Hospital and Research Institute, were enrolled. They received postoperative vinorelbine at 25mg/m(2) on days 1 and 8, and cisplatin 25mg/m(2) on days 1 to 3, this regimen being repeated every 3 weeks. Results: Median age was 49 years (range, 25-69 years). A ccording to the TNM stage system, stage.,.,. A patients accounted for 7.7%, 58.2% and 34.1%, respectively. The median number of chemotherapy cycles was 4.5 (range, 1-8), over half of the patients receiving 4 to 6 NP cycles. After a median follow-up of 48 months, 11 deaths and 29 relapses were documented. Median disease-free survival was 45 months, with disease-free and overall survival at 5 years being 76% and 88.7%, respectively. All patients could be evaluated with regard to toxicity, 17 (18.7%) developing grade III neutropenia during treatment, but all recovering after recombinant human granulocyte colony stimulating factor (G-CSF) injection, 3 suffering thrombocytopenia (3.3%), 5 anemia (5.5%) and 5 nausea/vomiting (5.5%). No treatment related deaths occurred. Conclusions: NP is an effective and feasible treatment for completely resected breast cancer cases at the doses tested. A randomized clinical trial is now needed to compare NP with other conventional regimens.
- 出版日期2011
- 单位江苏省肿瘤防治研究所
