Apparatus-Dependent Dosimetric Differences in Spine Stereotactic Body Radiotherapy

作者：Ma Lijun; Sahgal Arjun^*; Cozzi Luca; Chang Eric; Shiu Almon; Letourneau Daniel; Yin Fang Fang; Fogliata Antonella; Kaissl Wolfgang; Hyde Derek; Laperriere Normand J; Shrieve Dennis C; Larson David A

来源：Technology in Cancer Research and Treatment, 2010, 9(6): 563-574.

DOI：10.1177/153303461000900604

• Treatment planning
• Spine
• Stereotactic body radiotherapy
• Protons
• Radiosurgery

The purpose of this investigation was to study apparatus-dependent dose distribution differences specific to spine stereotactic body radiotherapy (SBRT) treatment planning. This multi-institutional study was performed evaluating an image-guided robotic radiosurgery system (CK), intensity modulated protons (IMP), multileaf collimator (MLC) fixed-field IMRT with 5 mm (11 field), 4 mm (9 field), and 2.5 mm (8- and 9-field) leaf widths and intensity modulated volumetric arc therapy (IMVAT) with a 2.5 mm MLC. Treatment plans were systematically developed for targets consisting of one, two and three consecutive thoracic vertebral bodies (VBs) with the esophagus and spinal cord contoured as the organs at risk. It was found that all modalities achieved acceptable treatment planning constraints. However, following normalization fixed field IMRT with a 2.5 mm MLC, IMVAT and IMP systems yielded the smallest ratio of maximum dose divided by the prescription dose (MD/PD) for one-, two- and three-VB PTVs (ranging from 1.1-1.16). The 2.5 mm MLC 9-field IMRT, IMVAT and CK plans resulted in the least dose to 0.1 cc volumes of spinal cord and esophagus. CK plans had the greatest degree of target dose inhomogeneity. As the level of complexity increased with an increasing number of vertebral bodies, distinct apparatus features such as the use of a high number of beams and a finer leaf size MLC were favored. Our study quantified apparatus-dependent dose-distribution differences specific to spine SBRT given strict, but realistic, constraints and highlights the need to benchmark physical dose distributions for multi-institutional clinical trials.

• 出版日期2010-12