Axitinib Affects Cell Viability and Migration of a Primary Foetal Lung Adenocarcinoma Culture

作者：Menna, Cecilia; De Falco, Elena; Pacini, Luca; Scafetta, Gaia; Ruggieri, Paola; Puca, Rosa; Petrozza, Vincenzo; Ciccone, Anna Maria; Rendina, Erino Angelo; Calogero, Antonella; Ibrahim, Mohsen^*

来源：Cancer Investigation, 2014, 32(1): 13-21.

DOI：10.3109/07357907.2013.861472

• Fetal lung adenocarcinoma
• Lung adenocarcinoma
• Vascular endothelial growth factor
• Axitinib
• Antineoplastic drugs
• Cancer primary cell cultures

Fetal lung adenocarcinoma (FLAC) is a rare variant of lung adenocarcinoma. Studies regarding FLAC have been based only on histopathological observations, thus representative in vitro models of FLAC cultures are unavailable. We have established and characterized a human primary FLAC cell culture, exploring its biology, chemosensitivity, and migration. FLAC cells and specimen showed significant upregulation of VEGF(165) and HIF-1 alpha mRNA levels. This observation was confirmed by in vitro chemosensitivity and migration assay, showing that only Axitinib was comparable to Cisplatin treatment. We provide a suitable in vitro model to further investigate the nature of this rare type of cancer.

• 出版日期2014-1