Diffusion tensor imaging of normal-appearing white matter in unilateral cerebral arterial occlusive disease

作者：Meng, Xiangshui; Wang, Qing; Hou, Jinwen; Zhang, Xiaoming; Wang, Enguo; Li, Qilu; Zeng, Qingshi; Wang, Qian; Li, Chuanfu; Ma, Xiangxing^*

来源：Journal of Magnetic Resonance Imaging, 2013, 38(3): 650-654.

DOI：10.1002/jmri.24004

• magnetic resonance imaging
• diffusion tensor imaging
• cerebral arterial occlusion
• chronic cerebral ischemia

Purpose To use MR with diffusion tensor imaging (DTI) and conventional and high b value to assess diffusion changes in normal-appearing white matter (NAWM) in patients with unilateral, severe stenosis, or occlusion of the middle cerebral artery (MCA). @@@ Materials and Methods In total, 28 patients with NAWM and unilateral, severe stenosis, or occlusion of the MCA underwent DTI with b values 1000 and 2200 s/mm(2) at 3.0T MR. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), radial diffusivity (eigenvalues (1), (2)), and axial diffusivity (eigenvalue (3)) were measured for the ipsilateral and contralateral corona radiata. @@@ Results Mean FA was significantly lower for the ipsilateral than contralateral corona radiata with high b value, 2200 s/mm(2), and ipsilateral corona radiata with conventional low b value, 1000 s/mm(2) (all P < 0.01). Mean ADC, (1), (2), and (3) were significantly higher for the ipsilateral than contralateral corona radiata with high b value (all P < 0.05) but not for ipsilateral than contralateral corona radiata with low b value (P > 0.05). @@@ Conclusion DTI with a high b value detects diffusion changes in NAWM in patients with unilateral, severe stenosis, or occlusion of the MCA not seen with conventional b value or conventional MRI contrasts. J. Magn. Reson. Imaging 2013;38:650-654.

• 出版日期2013-9
• 单位山东大学