Assessment of In-vivo Toxicity of Composite Materials Based on Poly-L-lactic Acid and -Tricalcium Phosphate

作者：Xiong, Lizhi^*; He, Zeqiang

来源：Polymer - Plastics Technology and Engineering, 2011, 50(2): 136-140.

DOI：10.1080/03602559.2010.531419

• -tricalcium phosphate
• Composite materials
• In-vivo cytotoxicity
• Poly-L-lactic acid

On the investigation of the in-vitro cytotoxicity of composite materials containing poly-L-lactic acid (PLLA) and -tricalcium phosphate (-TCP), the second part of the in-vivo cytotoxicity was investigated by acute systemic toxicity test, haemolytic test, skin sensitisation test, micronucleus test and subcutaneous implant test. The results indicated that there was no toxicosis or death cases observed in acute systemic toxicity test. The PLLA/-TCP composite showed no genetic toxicity and sensitising response, and the haemolytic index was 0.39%. The histological observation of the tissue response showed that the inflammatory response to PLLA/-TCP continued to decrease, which indicated the composite materials had a good biocompatibility. Therefore, PLLA/-TCP composite materials can be a promising candidate of biomedical materials for bone tissue engineering.

• 出版日期2011
• 单位吉首大学