科研之友
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摘要
Listeria monocytogenes, although an uncommon cause of illness in the general population, is an important pathogen in pregnants, neonates, elderly and immunocompromised patients. Neonatal listeriosis is classified as early (< 5 days) and late (>= 5 days) according to the onset of the symptoms and findings of the infection. The most encountered serotypes in early neonatal listeriosis are 1a and 1b, while serotype 4a is more prevalent in the late form. In this report, a neonatal L.monocytogenes meningitis case developed-in a female infant born after 36 weeks of gestation from a 29 years old mother, was presented. The newborn was hospitalized in intensive care unit because of low birth weight (1740 g) and prematurity. Due to the worsening of her general condition (feedings difficulty, tachypnea, high fever and bulging fontanel) on the 11(th) day, blood and cerebrospinal fluid (CSF) cultures were done. CSF culture yielded catalase positive, oxidase negative, gram-positive bacilli on the 4(th) day of cultivation. The isolate was identified as Listeria monocytogenes and found susceptible to all tested antibiotics (erythromycin, gentamicin, penicillin, trimethoprim-sulphamethoxazole, vancomycin, teicoplanin) by automated identification and antibiogram system (VITEC 2, bioMerieux, France). The empirical treatment initiated with vancomycin and meropenem was changed to ampicillin and gentamicin and clinical and microbiological response was obtained. The isolate was serotyped as type 1/2b. No data related to maternal infection or environmental contamination were obtained from the studies investigating the origin of infection. There have been no reported cases of neonatal Listeria meningitis from Turkey in the avaliable literature. This was the first case of neonatal Listeria meningitis in our country and it was presented to withdraw attention to L.monocytogenes serotype 1/2b which was a rare cause of late onset neonatal listeriosis.
- 出版日期2011-7
