2,6-Bis(benzimidazol-2-yl)pyridine as a potent transmembrane anion transporter

作者：Peng, Chen-Chen; Li, Zhi; Deng, Li-Qun; Ke, Zhuo-Feng; Chen, Wen-Hua^*

来源：Bioorganic & Medicinal Chemistry Letters, 2016, 26(10): 2442-2445.

DOI：10.1016/j.bmcl.2016.03.114

• Anionophore
• Benzimidazole
• Anionophoric activity
• Ion selectivity

2,6-Bis(benzimidazol-2-yl)pyridine was shown to exhibit potent anionophoric activity via a process of both Cl /NO3 antiport and H+/Cl symport. This is in sharp contrast to the finding that its corresponding N-methylated analog exhibited negligible activity and reveals the importance of the imidazolyl-NH fragments in the anion-transport process.

• 出版日期2016-5-15
• 单位南方医科大学; 中山大学