Mastitis Modifies the Biogenic Amines Profile in Human Milk, with Significant Changes in the Presence of Histamine, Putrescine and Spermine

作者：Perez Marta; Ladero Victor; Redruello Begoma; del Rio Beatriz; Fernandez Leonides; Miguel Rodriguez Juan; Cruz Martin Ma; Fernandez Maria^*; Alvarez Miguel A

来源：PLos One, 2016, 11(9): e0162426.

DOI：10.1371/journal.pone.0162426

Biogenic amines (BAs) are low molecular weight nitrogenous organic compounds with different biological activities. Putrescine, spermidine and spermine are essential for the development of the gut and immune system of newborns, and are all found in human milk. Little is known, however, about the role of histamine, tyramine or cadaverine in breast milk. Nor is it known whether mastitis alters the BA composition of milk. The BA profile of human milk, and the influence of mastitis on BA concentrations, were therefore investigated. Putrescine, spermidine and spermine were the main BAs detected. In mastitis-affected milk, the concentrations of putrescine, spermine and histamine were higher.

• 出版日期2016-9-1