Deregulation of microRNA-193b affects the proliferation of liver cancer via myeloid cell leukemia-1

作者：Yin, Wenjun; Nie, Yuehua; Chen, Lingying; Wang, Quipping; Liu, Shuangquan; He, Xiusheng^*; Wang, Wenjun^*

来源：Oncology Letters, 2018, 15(3): 2781-2788.

DOI：10.3892/ol.2017.7690

• microRNA-193b
• liver cancer
• cell proliferation
• myeloid cell leukemia-1

Deregulation of microRNA (miR)-193b has been revealed to be associated with the proliferation of liver cells. However, the interaction between miR-193b and their targets inducing liver cancer remains largely unknown. The aim of the present study was to investigate the hypothesis that miR-193b affects the proliferation of liver cancer cells. In the present study, the overall survival of patients with liver cancer and low fold change of miR-193b was higher compared with that of patients with liver cancer patients and high fold change of miR-193b. The expression level of myeloid cell leukemia-1 (Mcl-1) in patients with liver cancer was lower compared with in the control group. The results of the present study demonstrated that downregulation of miR-193b suppressed the proliferation and induced apoptosis of liver cancer cells, and inhibited the Mcl-1 protein expression level in liver cancer cells. Upregulation of miR-193b increased cell proliferation and decreased apoptosis of liver cancer cells and promoted the expression level of Mcl-1 protein. The results of the present study demonstrated that the expression of miR-193b as a novel tumor suppressor serves an important role in the proliferation of liver cancer cells by mediating Mcl-1 expression.

• 出版日期2018-3
• 单位南华大学