科研之友
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摘要
Objective: To assess the therapeutic efficacy of thymectomy as a treatment for myasthenia gravis (MG) by meta-analyses. Methods: Through the retrieval of related literature in Chinese National Knowledge Infrastructure database (CNKI), Wan Fang database, CiNii, NCBI, EBSCO, Web of Science and so on, the data, which concerned with thymectomy for myasthenia gravis and published from 2010 to 2016, were obtained. The meta-analysis of operating time, drainage time, hemorrhage volume and therapeutic efficacy were carried out by RevMan5.2 statistical software. Results: Seventeen foreign literature, were included in this study, with 642 cases of the video-assisted thoracic surgery (VATS) group and 603 cases of the sternotomy group. The analysis revealed that the hemorrhage volume of VATS thymectomy group was markedly less than conventional group (RR=6.25, P=0.01), while the drainage time was longer than that of conventional group (RR=1.26, P=0.12). No significant difference of MG improvement rate was found between both groups (RR=1.00, P=0.16). Conclusion: VATS thymectomy is a safe and reliable treatment for myasthenia gravis and it shares the same prostecdtive efficacy with conventional thymectomy. Combined with thoracoscopic surgery, the hemorrhage volume can be decreased and the hospital stay can be shortened in thymectomy.
- 出版日期2017
- 单位浙江中医药大学; 浙江省人民医院
