Association Between Genetic Polymorphisms of beta(2) Adrenergic Receptors and Nocturnal Asthma in Egyptian children

作者：Karam R A; Sabbah N A^*; Zidan H E; Rahman H M A

来源：Journal of Investigational Allergology and Clinical Immunology, 2013, 23(4): 262-266.

• Nocturnal asthma
• Egyptian children
• B-2 adrenergic receptor polymorphisms
• Allergy
• Polymorphism

Background: Identification of the genetic basis of asthma may contribute to the discovery of effective asthma drugs.
Objective: Our aim was to estimate the association between B-2 adrenergic receptor (ADRB2) polymorphisms and nocturnal asthma in Egyptian children.
Methods: ADRB2 polymorphisms Gly16 and Glu27 were genotyped in 200 Egyptian children (90 with nocturnal asthma and 110 healthy controls) using allele-specific polymerase chain reaction.
Results: The homozygous (Gly16) genotype significantly increased the risk of nocturnal asthma (odds ratio [On 3.2; 95% CI, 1.3-7.7; P=.003), as did the Gly allele (OR, 1.8: 95% CI, 1.2-2.8).
Conclusions: Our study demonstrated that nocturnal asthma was associated with ADRB2 Arg/Gly polymorphisms but not with ADRB2 Gln/Glu polymorphisms.

• 出版日期2013