Comparison of single voxel brain MRS AT 3 T and 7 T using 32-channel head coils

作者：Pradhan Subechhya^*; Bonekamp Susanne; Gillen Joseph S; Rowland Laura M; Wijtenburg S Andrea; Edden Richard A E; Barker Peter B

来源：Magnetic Resonance Imaging, 2015, 33(8): 1013-1018.

DOI：10.1016/j.mri.2015.06.003

• Brain
• Magnetic resonance spectroscopy
• 3 Tesla
• 7 Tesla
• Semi-LASER

Purpose: The purpose of this study was to compare magnetic resonance spectroscopy (MRS) of three different regions of the human brain between 3 and 7 Testa, using the same subjects and closely matched methodology at both field strengths.
Methods: A semi-LASER (sLASER) pulse sequence with TE 32 ms was used to acquire metabolite spectrum along with the water reference at 3 land 7 T using similar experimental parameters and hardware at both field strengths (n = 4 per region and field). Spectra were analyzed in LCModel using a simulated basis set.
Results: Signal-to-noise ratio (SNR) at 7 T was higher compared to 3 T, and linewidths (in ppm) at both field strengths were comparable in ppm scale. Of the 13 metabolites reported in the paper, most metabolites were measured with higher precision at 7 T in all three regions.
Conclusion: The study confirms gains in SNR and measurement precision at 7 T in all three representative brain regions using the sLASER pulse sequence coupled with a 32-channel phased-array head coil.

• 出版日期2015-10