Arresting cancer proliferation by controlling the surface crystallinity of carbon materials without generating reactive oxygen species

作者：Choi Jungil; Lee Soyoung; Wang Wenping; Hahm Soo Hyun; Han Ye Sun; Nam Tae Hyun; Kim Sang Hyun; Kang Sang Soo^*; Khang Dongwoo

来源：Acta Biomaterialia, 2012, 8(9): 3457-3467.

DOI：10.1016/j.actbio.2012.05.013

• Carbon nanostructures
• Crystallinity
• Cancer proliferation
• Reactive oxygen species
• Cytotoxicity

This study demonstrated that the surface crystallinity of carbon nanostructures is an additional independent factor that should be considered for the inhibition of cancer proliferation without activating reactive oxygen species (ROS). In addition, cytotoxic evaluation of both proliferating cancer cells and fully differentiated nerve cells (i.e. non-proliferative) showed selective cytotoxicity: single-walled and highly crystalline carbon nanostructures aggressively inhibited the proliferation of glioma cancer cells, but exhibited no notable cytotoxicity effects on differentiated nerve cells. Although single-wall carbon nanotubes have been shown to elicit potent proinflammatory responses by means of trigger ROS, our results demonstrated that highly crystalline carbon structures can be utilized as a selective antiproliferative agent against brain tumor cells without increasing the ROS level and without significant cytotoxic effects to adjacent nerve cells.

• 出版日期2012-9