MicroRNA-486-5p targets FGF9 and inhibits colorectal cancer proliferation, migration and invasion

作者：Gan, Jun; Hu, Cheng-En^*

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(5): 5258-5266.

• Colorectal cancer
• miR-486-5p
• FGF9
• proliferation
• invasion

Colorectal cancer (CRC) is one of the most common malignancies worldwide, and microRNAs (miRNAs), which act as tumor suppressors or oncogenes, are involved in CRC development and progression. The purpose of this study was to investigate the function and potential mechanism of miR-486-5p in CRC. The results showed that miR-486-5p was significantly down-regulated in CRC cell lines and tissues. Over-expression of miR-486-5p significantly inhibited cell proliferation, migration and invasion in vitro and suppressed tumor growth in vivo. Fibroblast growth factor 9 (FGF9) was identified as a direct target of miR-486-5p in CRC cells, and FGF9 expression was negatively correlated with miR-486-5p expression in clinical specimens. Enforced expression of FGF9 significantly reversed the tumor suppressive effects of miR-486-5p. Taken together, these findings revealed a functional and mechanistic link between miR-486-5p and FGF9 in the pathogenesis of CRC and miR-486-5p has potential as a therapeutic target for CRC.

• 出版日期2016
• 单位复旦大学