Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China

作者：Qiu S; Xu X; Wang Y; Yang G; Wang Z; Wang H; Zhang L; Liu N; Chen C; Liu W; Li J; Su W; Jia L; Wang L; Jin H; Keim P; Yuan Z; Huang L; Song H^*

来源：Clinical Microbiology and Infection, 2012, 18(4): E95-E98.

DOI：10.1111/j.1469-0691.2012.03768.x

• Banding pattern
• Ciprofloxacin resistance
• genetic diversity
• sequence type
• Shigella flexneri subserotype 1c

We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.

• 出版日期2012-4
• 单位中国人民解放军军事医学科学院; 上海市疾病预防控制中心; 厦门大学