A concise and simple synthesis of 1-hydroxy-phenethylamine derivatives: Formal synthesis of naturally occurring norephedrine, virolin and 3-hydroxy-2-phosphonylmethoxypropyl adenine

作者：Saha S; Chakraborty P; Roy S C^*

来源：Journal of Chemical Sciences, 2014, 126(3): 837-846.

DOI：10.1007/s12039-014-0616-x

• Synthesis
• 1-hydroxy-phenethylamine derivatives
• intermediates
• bio-active
• small molecules

A concise and simple synthesis of 1-hydroxy-phenethylamine derivatives has been achieved following classical organic transformations using commercially available chiral pools. The said derivatives were explored for the synthesis of naturally occurring bio-active small molecules. Formal synthesis of norephedrine, virolin and 3-hydroxy-2-phosphonylmethoxypropyl adenine has been demonstrated.

• 出版日期2014-5