A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

作者：White James R; Price Gareth J; Schiffers Stefanie; Raithby Paul R; Plucinski Pawel K; Frost Christopher G^*

来源：Tetrahedron Letters, 2010, 51(30): 3913-3917.

DOI：10.1016/j.tetlet.2010.05.104

The stable benzylaziclo-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.

• 出版日期2010-7-28