A Clinic-based Survey of Clinical Characteristics and Practice Pattern of Dry Eye in Japan

作者：Kawashima Motoko^*; Yamada Masakazu; Suwaki Kazuhisa; Shigeyasu Chika; Uchino Miki; Hiratsuka Yoshimune; Yokoi Norihiko; Tsubota Kazuo

来源：Advances in Therapy, 2017, 34(3): 732-743.

DOI：10.1007/s12325-017-0487-x

• Cross-sectional study
• Dry eye
• Prevalence
• Tears
• Treatment

Introduction: The aim of this study was to investigate the clinical characteristics and practice pattern of patients with dry eye disease (DED) in eye clinics across Japan.
Methods: A multi-center, cross-sectional study was conducted among patients with DED who visited eye clinics in Japan. Subjective symptoms, patient's background, ocular surface features, and tear function were evaluated. Main outcome measures were tear break-up time (TBUT), Schirmer I value, kerato-conjunctival staining score, and dry eye symptom questionnaire score.
Results: Initially, 463 subjects were enrolled, and 449 cases (63 male and 386 female; mean age, 62.6 +/- 15.7 years) were included in the final analysis. Overall, 94.9% of patients had a shortened TBUT (<= 5 s), and 54.6% had an aqueous tear deficiency (Schirmer I value <= 5 mm). The most prevalent subtype of dry eye was aqueous-deficient dry eye, which was present in 35.0% of all patients, followed by short-BUT-type dry eye, which was seen in 26.7%.
Conclusion: The two most common DED sub-types were aqueous-deficient and short-BUT-type dry eye. Shortened TBUT is the most common feature of dry eye, regardless of subtype. The current treatment choice mainly consisted of hyaluronic acid, two novel mucin secretagogues, diquafosol and rebamipide, and steroidal eye drops.

• 出版日期2017-3