Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: a new and improved trap for the detection of superoxide

作者：Hardy Micael; Chalier Florence; Ouari Olivier; Finet Jean Pierre; Rockenbauer Antal; Kalyanaraman Balaraman; Tordo Paul^*

来源：Chemical Communications, 2007, (10): 1083-1085.

DOI：10.1039/b616076j

Mito-DEPMPO, a new DEPMPO analogue bearing a triphenylphosphonium group, was synthesized via a novel NH2-reactive DEPMPO. The half-life of the Mito-DEPMPO superoxide adduct was estimated to be ca. 40 min. Using Mito-DEPMPO, reactive oxygen species generated in intact mitochondria were detected and characterized by EPR.

• 出版日期2007