A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with type 1 diabetes

作者：Rudofsky G^*; Schlotterer A; Humpert P M; Tafel J; Morcos M; Nawroth P P; Bierhaus A; Hamann A

来源：Experimental and Clinical Endocrinology & Diabetes, 2008, 116(1): 14-17.

DOI：10.1055/s-2007-985357

• small ubiquitin-related modifiers
• SUMO4
• polymorphism
• diabetic retinopathy
• type 1 diabetes

Aims: We studied the association between a functionally relevant M55V polymorphism in the SUMO4 gene with microvascular diabetic complications in patients with type 1 diabetes.
Methods: 223 patients with type 1 diabetes were studied using polymerase chain reaction and subsequent cleavage by restriction endonucleases for the M55V SUMO4 gene variant.
Results: No effect of the polymorphism on diabetic neuropathy or diabetic nephropathy was found, but heterozygous or homozygous patients for the M55V polymorphism in the SUMO4 gene had a markedly reduced prevalence of diabetic retinopathy (odds ratio 0.37, 95%-confidence interval (CI) [0.32;0.43]; p=0.004). Furthermore, a multiple logistic regression model showed an age and diabetes duration independent effect of the M55V polymorphisms on the prevalence of diabetic retinopathy (p = 0.03), but not of diabetic neuropathy or nephropathy.
Conclusions: Our data indicate that the M55V polymorphism in the SUMO4 gene is associated with a reduced risk of diabetic retinopathy in type 1 diabetes. Thus, the results of our study suggest that posttranslational modification of proteins via SUMO4 could contribute to the development of certain diabetic complications.

• 出版日期2008-1