A novel direct synthesis of 3-acyl-4-aryldihydroquinolin-2(1H)-ones via metal-free radical tandem cyclization between N-arylcinnamamides and aldehydes

作者：Mai, Wen-Peng^*; Wang, Ji-Tao; Xiao, Yong-Mei; Mao, Pu; Lu, Kui

来源：Tetrahedron, 2015, 71(42): 8041-8051.

DOI：10.1016/j.tet.2015.08.054

• Metal-free
• C-H functionalization
• Radical
• Cyclization
• 6-Endo trig

An efficient metal-free and practical method for the synthesis of disubstituted dihydroquinolin-2(1H)-ones via intermolecular radical tandem additionicyclization was developed. This method provides a novel and straightforward route to 3-acy1-4-aryldihydroquinolin-2(1H)-ones in one step by C-H functionalization. A possible mechanism for the formation of 3,4-dihydroquinolin-2(1H)-ones is also proposed.

• 出版日期2015-10-21
• 单位河南工业大学; 河南工程学院