A fast, highly sensitive and selective assay of iodide ions with single-stranded DNA-templated copper nanoparticles as a fluorescent probe for its application in Kunming mice samples

作者：Chen, Zhenzhen; Niu, Yaxin; Cheng, Guiying; Tong, Lili; Zhang, Guanglu; Cai, Feng; Chen, Tingting; Liu, Bao; Tang, Bo^*

来源：Analyst, 2017, 142(15): 2781-2785.

DOI：10.1039/c7an00595d

• UP-CONVERSION NANOPARTICLES
• LABEL-FREE
• NANOCLUSTERS
• ANIONS
• CHEMOSENSOR
• NANOPROBE
• STRATEGY
• CHLORIDE
• SENSOR

The development of fast, sensitive, selective and flexible methods for the detection of iodide is highly demanded and is of great significance. In this work, single-stranded DNA-templated copper nanoparticles (ssDNA-CuNPs) generated by sodium ascorbate reduction of Cu2+ along the single-stranded DNA of poly-T were utilized as a fluorescent probe for the determination of iodide ions (I-). The detection scheme is based on the instant quenching of the fluorescence of ssDNA-CuNPs by iodide ions. I- can be quantified in the concentration range from 0.050 to 40 mu M and from 40 to 80 mu M, and the limit of detection is as low as 15 nM. This method provides a simple and convenient strategy for the biochemical assay of I-, which is also helpful for early diagnosis of related diseases. The establishment of a low cost and fast detection method would be particularly important in developing countries where medical supplies are lacking.

• 出版日期2017-8-7
• 单位山东师范大学