Al-MCM-41 catalyzed three-component Strecker-type synthesis of alpha-aminonitriles

作者：Iwanami Katsuyuki; Seo Hana; Choi Jun Chul; Sakakura Toshiyasu; Yasuda Hiroyuki^*

来源：Tetrahedron, 2010, 66(10): 1898-1901.

DOI：10.1016/j.tet.2010.01.001

• Three-component Strecker-type reaction
• alpha-Aminonitriles
• Heterogeneous catalysis
• Mesoporous materials
• Al-MCM-41

Mesoporous aluminosilicate (Al-MCM-41) efficiently catalyzed the three-component Strecker-type reaction of benzylacetone and aniline with trimethylsilyl cyanide in CH2Cl2 at room temperature to afford the corresponding alpha-aminonitrile in excellent yields (up to 97%). Mesoporous silica (MCM-41), amorphous SiO2-Al2O3, and H-Y and H-ZSM-5 zeolites also catalyzed this reaction, but gave the desired product in lower yields. The Al-MCM-41 catalyzed three-component Strecker-type reaction was applicable to a wide range of ketones, aldehydes, and amines. Furthermore, the Al-MCM-41 catalyst could be applied to a fixed-bed flow reactor: The desired alpha-aminonitrile derivative was constantly produced in nearly 80% yields for 48 h.

• 出版日期2010-3-6